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Several studies have shown that the blood vessels carrying oxygen-rich blood to the brain are larger in males than in females. One study showed that men who had large blood vessels near the penis were more likely to develop erectile dysfunction. Large blood vessels are thought to be associated with increasing the chances of developing cardiovascular disease. Because this condition often manifests as heart disease, researchers conducted a Malegraclinical trial to see if this medication would reduce the risk of stroke and coronary artery disease. The results showed that more than half of the 615 male participants who took the drug had a lower risk of cardiovascular disease. The manufacturers of Malegra for men claim that this improvement in blood vessel size is the reason why men are less likely to experience cardiovascular problems associated with hypertension or suffer from erectile dysfunction associated with enlarged blood vessels.

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